Some of the first German settlers were Old Lutherans who founded the Freistadt community-now a neighborhood in western Mequon-in 1839 and went on to form the first Lutheran congregation in Wisconsin. Lutheranism has played a significant role in Mequon since the community's early years.

The City of Mequon completely surrounds Thiensville, leading some residents to call Thiensville 'Mequon's donut hole.' The two municipalities have a close relationship, with a shared chamber of commerce, library, and school district.

The community incorporated as a city in 1957 to avoid annexation by the City of Milwaukee. Mequon remained rural in the early 20th century but experienced significant population growth during the suburbanization that followed World War II. Thiensville incorporated as a village in 1910. Much of the community remained rural, while Thiensville developed as a market town along the local railway, providing services to the farmers. In the 1840s, German immigrants settled in the community, building farms and hydropowered mills along the Milwaukee River. When the first white settlers arrived in the 1830s, the Mequon area was inhabited by the Menominee, Potawatomi, and Sauk people. At the time of the 2010 census the population was 23,132. Despite being an incorporated city, approximately half of Mequon's land is undeveloped and agriculture plays a significant role in the local economy. Located on Lake Michigan's western shore with significant commercial developments along Interstate 43, the community is a suburb in the Milwaukee metropolitan area. state of Wisconsin, and the third-largest city in Wisconsin by land area. Mequon ( / ˈ m ɛ k w ɒ n/) is the largest city in Ozaukee County, in the U.S.

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